Using of 18 fluorine labeled prostatic specific membrane antigen positron emission tomography-computed tomography in staging of prostatic cancer in correlation with prostate specific antigen level

Background: Due to its biological properties, Prostate-specific membrane antigen (PSMA) is a good target for prostate cancer molecular imaging. The aim of this work was evaluate the role 18F PSMA Tomography–Computed Tomography (PET CT) in diagnosis and staging association with specific serum level. Methods: This prospective cohort performed on 30 individuals pathologically proven patients, seven patients were recently diagnosed referred primary disease, 27 long term who received initial treatment due high prostate-specific (PSA) Results: There positive between PSA values maximum standardized uptake (SUV max) expression at insignificant correlations age or SUV max metastatic lesions cancer. At 3.4 cut-off value, had 100% sensitivity specificity win active local prostatic higher AUC than PSA. among statistically significant difference. value equal 5.3, 95% 71.4% prediction metastasis.Conclusions: PET/CT modality choice recurrent prostate, it can assess site recurrence determine disease burden. It detect metastasis non-enlarged lymph nodes, bony deposits even no apparent CT morphological changes.